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XIENCE™ Family of Drug-Eluting Stents

The World's Leading Drug-Eluting Stents (DES), with Unparalleled Clinical Outcomes¹

AMI Patients

XIENCE™ Stent in AMI Patients

Low long-term event rates are critical for acute myocardial infarction (AMI) patients, and XIENCE™ Stent findings show excellent early outcomes in AMI patients.2 Contributing to these results are several features of XIENCE™ Stent:

  • Innovative stent design
  • Anti-thrombotic fluoropolymer3
  • Market-leading everolimus4


XIENCE™ Stent AMI Safety Data Apparent at 2 Weeks

The XIENCE™ Stent fluoropolymer exhibits improved anti-inflammatory characteristics compared to other drug-eluting stents (DES).3 This may be a key factor why the XIENCE™ Stent has such impressive safety data within 2 weeks post percutaneous coronary intervention (PCI) among AMI patients. Data show that—compared to immediately post intervention—XIENCE™ Stent reveals significant progression at 2 weeks post PCI2 in terms of:

  • Better strut coverage (p<0.01)
  • Less thrombus (p=0.03)
  • Larger average lumen area (p=0.048)

 

By 2 weeks post PCI XIENCE data shows ~80% strut coverage and significantly less thrombus than immediately post PCI.

Strut Coverage and Thrombosis2

In acute myocardial infarction patients, XIENCE Stent has a significantly larger lumen area at 2 weeks vs post implant.

Post PCI

In acute myocardial infarction patients, XIENCE Stent has a significantly larger lumen area at 2 weeks vs post implant.

2 Weeks Post PCI

Less Thrombosis, Larger Lumen Area at 2 Weeks2

XIENCE™ Stent 4-Year AMI Study5

A large, multicenter, real-world study revealed that the XIENCE™ Stent low clinical event rates at 1 year were sustained through 4 years—in both AMI and non-AMI patients.
 

At 1 Year and 4 Years No Significant Difference in AMI and Non-AMI Patients
 

Target lesion failure was not significantly different at 4 years, p<0.09, in AMI vs non-AMI patients.
Definite/probable stent thrombosis was not significantly different at 4 years, p<0.13, in AMI vs non-AMI patients.

EXAMINATION STEMI Data: Low XIENCE™ Stent Acute ST6

XIENCE™ Stent also demonstrates safety among ST-elevation myocardial infarction (STEMI) patients, a subgroup of AMI patients. At 30 days, the rate of definite stent thrombosis (ST) with XIENCE™ Stent vs bare metal stents (BMS) was significantly lower: 0.4% vs 1.6%, p=0.02.

In STEMI patients, the stent thrombosis rate with XIENCE Stent rate is 4 times lower than that of bare metal stents at 30 days.

XIENCE™ Stent STEMI Data at 1 Year6

At 12 months 98% of patients with STEMI are free of target lesion revascularization (TLR).

XIENCE Stent shows 98% Freedom from TLR at 1 Year.

XIENCE™ Stent Long-Term STEMI Data7

The EXAMINATION trial looked at the AMI subgroup of STEMI patients, a subgroup of AMI patients. At both 1 and 5 years XIENCE™ Stents performed better than BMS in an all-comer population.6,7

In STEMI patients, ST and TLR rates are lower with XIENCE Stent vs bare metal stents at both 1 and 5 years.
Event Rates at 1 and 5 Years

“The benefit of EES in ST-elevation myocardial infarction at long term is reassuring and confirms the use of [XIENCE™ Stent] second-generation stents as the current gold standard treatment in this clinical context.”
—Manel Sabaté, et al.7

XIENCE™ Stent Very Long-Term STEMI Data—7 Years8

A meta-analysis examined trials (n=1,581) comparing XIENCE™ Stent second generation DES vs first generation DES—sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES). XIENCE™ Stent conferred significantly lower rates of ST and target vessel revascularization (TVR) at 7 years.
 

XIENCE™ Stent vs First-Generation DES in STEMI Patients
 

Stent Thrombosis
7-year data show that, vs first generation DES, XIENCE second generation DES has significantly lower ST and TVR.
Target Vessel Revascularization
7-year data show that, vs first generation DES, XIENCE second generation DES has significantly lower ST and TVR.

Very Low 1-Year Event Rates in STEMI Registry9

One-year clinical outcomes from the XIENCE™ Stent STEMI Registry further revealed that the XIENCE™ Stent was associated with a low incidence of clinical events—including stent thrombosis—even in a high-risk STEMI population.
 

STEMI Registry shows XIENCE Stent with low 1.8% target vessel failure (primary endpoint).
STEMI Registry shows XIENCE Stent with low 2% MACE (cardiac death, MI, target lesion revascularization)
STEMI Registry shows XIENCE Stent with low 0.76% rate of definite ST.
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References

  1. Zanchin C, et al. JACC Cardiovasc Interv. 2019;12(17):1665-1675. Serruys P, et al. N Engl J Med. 2010;363:136-146. Shiomi H, et al. JACC Cardiovasc Interv. 2019;12:637-647. Kufner S, et al. Circulation. 2019:139(3):325-333. Palmerini T, et al. Lancet. 2013;379:1393-1402. Bangalore S, et al. Circulation. 2012;125:2873-2891. Bangalore S, et al. Circ Cardiovasc Interv. 2013;6(6):378-390. Pilgrim T, et al. Lancet. 2014;384:2111-2122. Pilgrim T, et al. Lancet. 2018;392:737-746. Data on file at Abbott.
  2. Morino Y, et al. Cardiovasc Interv Ther. 2019;34:14-24.
  3. Jinnouchi H, et al. J Am Coll Cardiol. 2019;74:Suppl B – TCT-291.
  4. Data on file at Abbott.
  5. Sudhir K, et al. J Am Coll Cardiol. 2014;64(11 Suppl) – TCT-39.
  6. Sabaté M, et al. Lancet. 2012;380:1482-1490.
  7. Sabaté M, et al. Lancet. 2016;387:357-366.
  8. De Luca G, et al. Int J Cardiol. 2017;244:121-127.
  9. Otsuji S, et al. EuroPCR 2019 – XIENCE STEMI Registry.

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