The XIENCE™ Stent polymer with a fluorinated surface has shown protective attributes—the ability to tightly bind albumin to create a “protective cloak” around the stent.2
Another factor that sets XIENCE™ Stent apart is its fluoropolymer coating. Unlike other polymer coatings, the fluoropolymer interacts with proteins in the blood in a way that reduces thrombus formation—a process known as fluoropassivation.
XIENCE™ Stent, widely considered to be the gold standard for patient safety and efficacy, is coated with a fluoropolymer.
THE XIENCE FLUOROPOLYMER: PROVEN TO PROTECT
Due to thromboresistance and low inflammatory responses, fluorinated surfaces encourage faster endothelization and healing.4
Moreover, the XIENCE™ Stent fluoropolymer has minimal coating defects compared to biodegradable polymer DES (BP-DES).9
In contrast to the visual above, most stents available today—biodegradable polymer stents, durable polymer stents or bare metal stents—have non-fluorinated surfaces that interact with proteins in the following ways:
XIENCE™ Stent’s fluoropolymer demonstrates the fewest platelets adhering to the stent surface—an important factor in stent thrombosis.3 This fluoropolymer can protect patients from both acute and long-term complications.3,13
Representative confocal photomicrographs stained for platelets (CD42b/CD61). N=5 per stent. This preclinical ex vivo porcine shunt model used aspirin-only antiplatelet therapy.
Representative confocal photomicrographs stained for platelets (CD42b/CD61). N=8 per stent. This preclinical ex vivo porcine shunt model used clopidogrel-only antiplatelet therapy.
In the images “on the right you can see the [pro-thrombotic] platelet adherence. XIENCE™ Stent [the image at the bottom] has hardly any attachments to it.” — Renu Virmani, MD, referring to the photomicrographs, where green indicates platelet adhesion.
In several analyses, XIENCE™ Stent exhibits the most thromboresistance when compared to several different BP-DES.3,14
Ex vivo porcine photomicrographs reveal the least thrombus area on XIENCE™ Stent (green areas are platelets).
CVPath Institute also conducted tests to show real-time platelet-device interaction between different types of stents.
This preclinical model used in vitro human blood with heparin only. Representative confocal photomicrographs stained for platelets. Real-time platelet-device interaction was visualized under confocal microscopy and recorded in a time-lapse video. Image processing quantified platelet deposition on devices.
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