The market-leading choice for XIENCE™ Stent is everolimus, which is a proven therapeutic drug.2
An ideal drug for DES has these characteristics:
The everolimus drug provides all these features.
The release of everolimus aligns with the vessel's restenosis cascade. This, in turn, maximizes the drug's efficacy against restenosis and minimizes the drug's effect of re-endothelialization, which facilitates vessel restoration and function.
Everolimus Elution Correlates to Restenosis Cascade
Everolimus is a well established anti-proliferative drug. The concentration of everolimus used with XIENCE™ Stent is low, at 100 µg/cm². These histological images below show healthy, fully healed vessels at a concentration that is 8x the dose used on the XIENCE™ stent. Images were gathered using a pre-clinical animal model.
Everolimus Safety at 8x Drug Dose