The Amplatzer™ Family of Vascular Plugs

Amplatzer™ Vascular Plug 4
(AVP 4)

Low-profile embolization compatible with 0.038" guide wire compatible diagnostic catheters1 that reach distal vasculature through tortuous anatomy.2

  • Simple delivery through an 0.038” guide wire compatible diagnostic catheter1
  • Easy tracking through tortuous anatomy1
  • Extended reach to distal vasculature1
  • Select a device that is ~30-50% larger in diameter than the target vessel diameter1
amplatzer vascular plug
amplatzer vascular plug

Device Description1:

  • The device is shipped attached to a 155cm delivery wire in a hoop dispenser
  • The device is preloaded in a loader
  • A plastic vise is also included and may be attached to the delivery wire to facilitate device detachment.
  • 155 cm long PTFE-coated delivery wire
  • Compatibility with 0.038” diagnostic catheters


  • Plug: Nitinol
  • Delivery wire: PTFE-coated Stainless wire coil with NiTi core
  • Marker bands: Platinum
  • Micro screw: Stainless steel
 amplatzer vascular plug ii materials

Amplatzer™ Family of Vascular Plugs

Amplatzer™ Vascular Plug (AVP)

Amplatzer™ Vascular Plug II (AVP II)

Amplatzer™ Vascular Plug 4 (AVP 4)


  1. Amplatzer™ Vascular Plug 4 – Instructions for Use (IFU) 
  2. Lopera, Jorge E. “The Amplatzer vascular plug: review of evolution and current applications.” Seminars in interventional radiology. Vol. 32. No. 04. Thieme Medical Publishers, 2015.

MAT-2002814 v1.0

Important Safety Information

AMPLATZER™ Vascular Plug 4


Indications And Usage: The AMPLATZER™ Vascular Plug 4 is indicated for arterial and venous embolizations in the peripheral vasculature.

Contraindications: None known.


  • The safety and effectiveness of this device for cardiac uses (eg, cardiac septal occlusion, patent ductus arteriosus, paravalvular leak closures) and neurologic uses have not been established.
  • Do not use this device if the sterile package is open or damaged.
  • Use on or before the last day of the expiration month that is printed on the product packaging label.
  • The device was sterilized with ethylene oxide and is for single use only. Do not reuse or resterilize this device. Attempts to resterilize this device can cause a malfunction, insufficient sterilization, or harm to the patient.
  • Do not use a power injection syringe to inject contrast solution through this device.
  • Physicians must be prepared to deal with urgent situations, such as device embolization, which require removal of the device. This includes the availability of an on-site surgeon.


  • The AMPLATZER™ Vascular Plug 4 device consists of a nickel-titanium alloy, which is generally considered safe. However, in vitro testing has demonstrated that nickel is released from this device for a minimum of 60 days. Patients who are allergic to nickel may have an allergic reaction to this device, especially those with a history of metal allergies. Certain allergic reactions can be serious; patients should be instructed to notify their physicians immediately if they suspect they are experiencing an allergic reaction such as difficulty breathing or inflammation of the face or throat. Some patients may also develop an allergy to nickel if this device is implanted.
  • The physician should exercise clinical judgment in situations that involve the use of anticoagulants or antiplatelet drugs before, during, and/or after use of the device.
  •  Store in a dry place.
  • This device should be used only by physicians who are trained in standard endovascular techniques. The physician should determine which patients are candidates for procedures that use this device.
  • Use in specific populations
    • Pregnancy - care should be taken to minimize the radiation exposure to the
      fetus and the mother.
    • Nursing mothers - there has been no quantitative assessment of the presence
      of leachables in breast milk.

MRI Safety Information:

MRA patient with the Amplatzer™ Vascular Plug 4 may be safely scanned under the following conditions. Failure to follow these conditions may result in injury to the patient.
Device NameAmplatzer™ Vascular Plug 4
Static Magnetic Field Strength (B0)1.5 T or 3.0 T
Maximum Field Spatial Gradient19T/m (1900 gauss/cm)
RF ExcitationCircularly Polarized (CP)
RF Transmit Coil TypeBody Coil
Operating ModeNormal Operating Mode
Maximum Whole Body SAR2.0W/kg (Normal Operating Mode)
Maximum Head SARN/A
Scan Duration2.0W/kg whole-body-averaged SAR for 15 minutes of continuous scanning
MR Image ArtifactThe presence of this implant may produce an image artifact.


Potential Adverse Events: Potential adverse events that may occur during or after a procedure placing this device include, but are not limited to:

  • Air embolus
  • Allergic reaction/toxic effects
  • Bleeding
  • Death
  • Device migration
  • Fever
  • Foreign material embolic event
  • Hemolysis
  • Infection
  • Occlusion of unintended vessel
  • Peripheral embolism
  • Recanalization
  • Residual flow
  • Stroke/TIA
  • Surgical intervention
  • Vascular access site complication
  • Vessel trauma/perforation

State of California (USA) Only:

WARNING: This product can expose you to chemicals including ethylene oxide, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to


MAT-2004318 v3.0