PressureWire™ X Guidewire

for Wireless Physiology

Objective Decisions.
Simplified Workflow.

Abbott’s newest generation of the PressureWire™ X Guidewire offers objective decisions with a simplified workflow.1

The innovative PressureWire™ X Guidewire—the world’s only wireless physiology wire2—can measure pressure and temperature to calculate Abbott's Resting Full-Cycle Ratio (RFR), Fractional Flow Reserve (FFR), Index of Microvascular Resistance (IMR), and Coronary Flow Reserve (CFR). The guidewire’s fully integrated, secure, wireless measurements are integral to a cardiac cath lab’s clinical physiology routine. Abbott’s PressureWire™ X Guidewire and Coroventis CoroFlow Cardiovascular System are the only solution for the cath lab able to detect both epicardial disease and Coronary Microvascular Dysfunction (CMD).1-4


 Pressurewire X Guidewire
PressureWire™ X Guidewire


 Pressurewire X Guidewire Packaging


 Pressurewire X Guidewire Sensor Housing
Sensor Housing Close-Up View

Objective Decisions

  • Innovative sensor housing design offers <1 mmHg/30 min with reduction in drift due to microbubbles5
  • Objective decision-making with both RFR and FFR options
  • RFR has been studied in over 3,500 lesions and 2,000 patients6-10 to show diagnostic equivalence to iFR.
84% reduced drift with the latest PressureWire X Guidewire compared to its previous sensor housing design

Simplified Workflow

  • The PressureWire™ X Guidewire is the world’s only wireless physiology wire2
  • Wireless: from zero to go in 2 easy steps2
  • Ideal for the modern radial approach­
  • Compatible with the QUANTIEN™ Measurement System with an easy touchscreen workflow
  • Compatible with OPTIS™ Imaging Systems for imaging and physiology needs on one platform
  • Compatible with the Coroventis CoroFlow Cardiovascular System for assessment of both epicardial disease and microvascular dysfunction11
Wireless PressureWire X Guidewire
2 Steps to Connect the Wireless
PressureWire™ X Guidewire1
  1. Zero. Zero the PressureWire™ X Guidewire by turning on the transmitter.
  2. Go. The transmitter’s function indicator shall display a stable green light when it is successfully zeroed.


  1. Data on file at Abbott.
  2. Volcano Corp. Verrata guidewire and PrimeWire Prestige Plus guidewire IFUs, Opsens Inc. OptoWire guidewire and OptoWire II guidewire IFUS, ACIST Medical Systems. Navvus Microcatheter IFU, Boston Scientific Corporation. Comet guidewire IFU, PressureWire™ X Guidewire IFU.
  3. Ford TJ, Stanley B, Sidik N, et al. 1-year outcomes of angina management guided by invasive coronary function testing (CorMicA). JACC Intv. 2020; 13:33-45.
  4. Pijls NH, Fearon WF, Tonino PA, et al. Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients with Multivessel Coronary Artery Disease. 2-Year Follow-Up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) Study. JACC. 2010; 56(3): 177-184.
  5. Test(s) performed by and data on file at Abbott.
  6. Jeremias A, et al. Resting full-cycle ratio (RFR): a novel physiologic index compared to Fractional Flow Reserve (FFR) in assessing the hemodynamic severity of a coronary stenosis: ILUMIEN I + PREDICT. EuroPCR 2018.
  7. Svanerud J, et al. Validation of a novel non-hyperemia index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. EuroIntervention. 2018;14:806-814.
  8. Ahn JM, et al. IRIS FFR: prognostic performance of five resting pressure-derived indexes of coronary physiology. TCT 2018.
  9. Kumar G. et al. Re-Validate Study. CRT 2019.
  10. Lee J-M, et al. Physiological and clinical assessment of resting physiological indexes. Circulation. 2019;139.
  11. Coroventis CoroFlow Cardiovascular System IFU.

MAT-2011811 v1.0


PressureWire™ X Guidewire


Indications: The PressureWire™ X Guidewire is indicated to direct a catheter through a blood vessel and to measure physiological parameters in the heart and in the coronary and peripheral blood vessels. Physiological parameters include blood pressure. The PressureWire™ X Guidewire can also measure blood temperature.

Contraindications: This guidewire is contraindicated for use in the cerebral vasculature.


  • No modification of this device is allowed.
  • The PressureWire™ X Guidewire is supplied sterile. Discard the guidewire if the pouch is opened or damaged, compromising the sterile barrier. The guidewire is designed for single use only and shall not be reused or resterilized. Adverse effects of using a non-sterile or resterilized guidewire may include, but are not limited to:
    • Local and/or systemic infection
    • Mechanical damage
    • Inaccurate readings
  • Observe all guidewire movements. Whenever the guidewire is moved or torqued, the tip movement should be examined under fluoroscopy. Never push, withdraw, or torque the guidewire if it meets resistance or without observing corresponding movement of the tip, otherwise vessel/ventricle trauma may occur.
  • Torquing or excessive manipulation of the guidewire in a sharp bend, against resistance, or repeated attempts to cross a total vessel occlusion may:
    • Cause dissection or perforation of blood vessels
    • Cause vessel spasm
    • Damage and/or fracture the guidewire
  • When introducing the guidewire, flush the catheter and administer anticoagulation as for a standard catheterization procedure or clotting may occur.
  • Do not use the guidewire in the ventricles if the patient has a prosthetic mechanical or biological valve. It may result in damage to both the prosthesis and the guidewire, which may cause injury or death.
  • Use of the PressureWire™ X Guidewire in conjunction with interventional devices with a short rapid exchange may result in a folded or fractured guidewire.
  • High frequency surgical devices must not be used on a patient at the same time as the guidewire.


  • The PressureWire™ X Guidewire is a delicate instrument and should be handled carefully.
  • Make sure that the transmitter is kept dry to ensure accurate pressure and/or temperature readings. Inaccurate readings may necessitate device replacement.
  • Do not use the guidewire in conjunction with atherectomy catheters. It may damage the guidewire.
  • Do not withdraw or manipulate the guidewire in a sharp-edged object. It may result in abrasion of the guidewire coating.
  • Factors that may affect the accuracy of the diagnostic information include, but are not limited to:
    • Improper placement of the aortic pressure sensor.
    • Failure to achieve maximum coronary and myocardial hyperemia in FFR procedures.
    • Blood flow affected by the position of interventional devices, such as balloon catheters.
  • Guidewire readings may be affected by defibrillation. Rezero the guidewire after defibrillation use.
  • Do not measure pressure when the guidewire sensor element is in a sharp bend or in contact with atrial or ventricular walls. It might result in pressure artifacts.
  • Do not use the PressureWire™ X Guidewire together with another guidewire, for so called jailed wire technique, due to difficulty in guidewire withdrawal and possible guidewire entrapment.
  • Store at room temperature (15°C – 25°C) in a dry and dark place.

Potential Adverse Events: Potential complications which may be encountered during all catheterization procedures include, but are not limited to: vessel dissection or occlusion, perforation, embolus, spasm, local and/or systemic infection, pneumothorax, congestive heart failure, myocardial infarction, hypotension, chest pain, renal insufficiency, serious arrhythmias, or death.

In addition, this device has a coating containing Polyethylene Glycol (PEG); potential allergic reactions (anaphylaxis) may occur during the interventional procedure if the patient is allergic to PEG.

MAT-2103599 v2.0