Outcomes for Female Patients with Advanced Heart Failure

an image of an older woman looking at a distance

Women with Heart Failure

Outcomes for Female Patients with Advanced Heart Failure

Outcomes are worse for women when heart failure is not being treated or recognized compared to their male counterparts.

Women’s Experience

Greater impact on their lives with more symptoms and worse general and disease-specific quality of life.^1,2
Greater self-reported psychological and physical disability, causing poorer quality of life.²
Higher stroke rate.²
Higher mortality rate due to higher serum digoxin levels despite similar doses.³
Higher rate of adverse events after ICD implantation. This may be due to differences in vascular access with smaller vessels and body size in women.³
Higher mortality rate due to cardiogenic shock.³
Higher risk of mortality during the first 4 months after LVAD implantation mainly due to neurological complications.³

Heart Failure Outcomes and Mortality

Median Age of Diagnosis

Women

79.6

Men

74.8

Diagnosed*

*within 17 year study period

Women

26,725

Men

29,234

Death Rates*

*within 17 year study period

Women

15,822

Men

15,084

Median Survival Rate Following Diagnosis

3.99 years for women and 4.47 years for men

an illustration of a man and a woman

Cause of Death

Women non CVD 44.8% CVD 55.2%

Men non CVD 43.9%, CVD 56.1%

What’s Next: Reduce the Knowledge Gap

References

Mary Norine Walsh, Mariell Jessup, JoAnn Lindenfeld (2019) Women With Heart Failure: Unheard, Untreated, and Unstudied, Journal Of The American College Of Cardiology, vol 73, n°1, p. 41-43, doi.org/10.1016/j.jacc.2018.10.041
Pooja Dewan, Rasmus Rørth, Pardeep S. Jhund, Li Shen, Valeria Raparelli, Mark C. Petrie, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Lars Køber, Ulrik M. Mogensen, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, John J.V. McMurray (2019) Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women, Journal Of The American College Of Cardiology, vol 73, n°1, p. 29-40, doi.org/10.1016/j.jacc.2018.09.081
Ersilia M. DeFilippis, Anna Beale, Trejeeve Martyn, Anubha Agarwal , Uri Elkayam , Carolyn S.P. Lam , Eileen Hsich (2022) Heart Failure Subtypes and Cardiomyopathies in Women Circulation Research. 2022;130:436–454. DOI: 10.1161/CIRCRESAHA.121.319900
Taylor et al.; National trends in heart failure mortality in men and women. United Kingdom, 2000-2017. Eur J Heart Failure. doi:10.1002/ejhf.1996.

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