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MOMENTUM 3 Trial

Publications and Presentations

Two-Year Primary Outcomes in the MOMENTUM 3 Long-Term Cohort

 

Mehra, M.R., Goldstein, D.J., Uriel, N., Cleveland, J.C., Yuzefpolskaya, M., Salerno, C., …, Naka, Y., for the MOMENTUM 3 Investigators. (2018). Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. N Engl J Med, 378(15), 1386-95. https://www.doi.org/10.1056/NEJMoa1800866

The data from the two-year MOMENTUM 3 trial pre-specified primary analysis demonstrates:

  • Durability of the HeartMate 3 LVAS to optimally support patients who wait for extended periods for heart transplantation or are ineligible for heart transplantation (destination therapy).
  • Clinical superiority of the HeartMate 3 LVAS when compared to the HeartMate II LVAS axial-flow pump.
  • Lowest published rates for both stroke and pump thrombosis at 2 years.
  • Lower rate of reoperation for pump malfunction in the HeartMate 3 LVAS arm.
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Healthcare Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Cohort

Mehra, M.R., Salerno, C., Cleveland, J.C., Pinney, S., Yuzefpolskaya, M., Milano, C. A., ... Silvestry, S.C. (2018)Healthcare Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Outcome Study: Randomized Controlled Trial of a Magnetically Levitated Cardiac Pump in Advanced Heart Failure. Circulation, 138(18), 1923-34. https://doi.org/10.1161/CIRCULATIONAHA.118.035722

In this two-year economic analysis of the MOMENTUM 3 trial, the HeartMate 3 LVAS in comparison with the HeartMate II LVAS demonstrated:

  • Reduction in rehospitalizations.
  • Reduction in hospital days spent during rehospitalizations.
  • Cost savings following discharge.
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Comprehensive Analysis of Stroke in the MOMENTUM 3 Long-Term Cohort

 

Colombo, P.C., Mehra, M.R., Goldstein, D.J., Estep, J.D., Salerno, C., Jorde, U.P., … Horstmanshof, D.A. (2019). Comprehensive Analysis of Stroke in the Long-Term Cohort of the MOMENTUM 3 Study: A Randomized Controlled Trial of the HeartMate 3 Versus the HeartMate II Cardiac Pump. Circulation, 139 (2), 155-168. https://doi.org/10.1161/CIRCULATIONAHA.118.037231

This comprehensive stroke analysis of the long-term cohort of the MOMENTUM 3 study shows the following:

  • In patients with advanced heart failure, the use of the HeartMate 3 LVAS lowers stroke rates when compared with the HeartMate II LVAS pump.
  • The occurrence of stroke of any type or any functional severity is predictive of a poor two-year clinical outcome.
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