Clinical Data to Support DeFT Response Technology

• DeFT Response technology in Abbott patients resulted in a significantly higher proportion of patients with satisfactory DFTs.⁵
• “Tuned” defibrillation waveforms outperform 50/50% tilt defibrillation waveforms.⁶

Optimizes Shock Performance With or Without A DFT Test⁵*

Method: Analysis of DFT levels for 105 patients implanted with a single coil lead between Aug 2007 and Aug 2010.

• Group A: patients with waveform tuning (Abbott)
• Group B: patients with fixed-tilt waveform (60% Boston Sci., 34% Medtronic, 6% Biotronik)

DFT Testing: VF induced by synchronized T-wave shock or direct current pulse. If initial shock failed, second shock delivered at highest energy within 10 J safety margin of device. If unsuccessful, a subcutaneous coil implanted and DFT test repeated. Note: the RV-coil was specifically programmed as an anode in all devices.

*Applies to single coil systems.

References

1. Leong-Sit, P., Gula, L. J., Diamantouros, P., Krahn, A. D., Skanes, A. C., Yee, R., & Klein, G. J. (2006). Effect of defibrillation testing on management during implantable cardioverterdefibrillator implantation. American Heart Journal, 152(6), 1104-1108.
2. Russo, A. M., Sauer, W., Gerstenfeld, E. P., Hsia, H. H., Lin, D., Cooper, J. M., ... Marchlinkski, F. E. (2005). Defibrillation threshold testing: is it really necessary at the time of implantable cardioverter-defibrillator insertion? Heart Rhythm, 2, 456-461.
3. Shukla, H. H., Flaker, G. C., Jayam, V., & Roberts, D. (2003). High defibrillation thresholds in transvenous biphasic implantable defibrillators: clinical predictors and prognostic implications. PACE, 26(1 Pt 1), 44-48.
4. Cooper, J., Latacha, M., Soto, G., Garmany, R. G., Gleva, M. J., Chen, J., ... Smith, T. W. (2008). The azygos defibrillator lead for elevated defibrillation thresholds: implant technique, lead stability, and patient series. PACE, 31, 1405-1410.
5. Gabriels, J., Budzikowski, A., & Kassotis, J. (2013). Defibrillation Waveform Duration Adjustment Increases the Proportion of Acceptable Defibrillation Thresholds in Patients Implanted with Single-Coil Defibrillation Leads. Cardiology, 124(2), 71-75.
6. Natarajan, S., Henthorn, R., Burroughs, J., Esberg, D., Zweibel, S., Ross, T., ... Oza, A. (2007). “Tuned” Defibrillation Waveforms Outperform 50/50% Tilt Defibrillation Waveforms: A Randomized Multi-Center Study. Pacing Clin Electrophysiol, 1, S139-42.