For more information about the LIFE-BTK study.
PAD is caused by a narrowing or blockage of the blood vessels (arteries) that carry blood from the heart to the rest of your body. PAD is most commonly caused by blockages that reduce blood flow to your legs, and cause symptoms like severe pain and sores that don't heal. It could even mean complete loss of blood circulation, which can cause body tissue to die. This is called gangrene and can lead to amputation of the affected body part if it goes untreated.
People with CLI often have chronic pain, even at rest, as well as ulcers and gangrene (tissue death) that develop as a result of long-term poor blood flow to the lower limbs.1
8.5 million people in the United States have PAD,2 but 75% of adults are not aware of the disease3
Diabetes, hypertension, smoking and obesity are major risk factors1,2
African American and Native American populations are at highest risk of the disease4,5
Up to 40% of patients with CLI currently undergo amputations.1 Amputation risk is highest among African Americans4