THE BURDEN OF MITRAL REGURGITATION
MR is a condition in which the heart's mitral valve leaflets do not close tightly. When this happens, blood flows backward from the heart's left ventricle into the left atrium. The heart must then work harder to push blood through the body, which can cause fatigue, shortness of breath, and worsening heart failure.2
MR is the most frequent valve disease in the United States.3,4 Over 4 million people have significant MR, with an annual incidence of 250,000.3-5 Prevalence and incidence are similar in Europe, where it's the second most common type of heart valve disease.6 The disease affects millions of people worldwide.
ESC/EACTS TREATMENT GUIDELINES
For symptomatic patients diagnosed with moderate-severe or severe MR, surgery is generally recommended to repair or replace the mitral valve. This typically involves open-heart surgery with the patient on cardiopulmonary bypass.1,6
According to the 2017 ESC/EACTS Guidelines for the Management of Valvular Heart Disease, transcatheter mitral valve repair (TMVr) with MitraClip therapy may be considered for patients with severe MR who are not suitable for surgery.6