MultiPoint Pacing has been proven to elevate cardiac resynchronization therapy (CRT) response.1 Abbott has built on the quadripolar standard of care to offer more pacing options for your patients.
Quadra Allure MP CRT-P allows patients to undergo MRI scans when used with MRI Ready leads from Abbott. This device has been tested for safe performance of an MRI scan using a 1,5 T (Tesla) field-strength MRI scanner.a
ONE LEAD. TWO IMPULSES. MORE OPTIONS TO MANAGE CRT RESPONSE.
Quadra Allure MP CRT-P offers the only complete quadripolar system with MultiPoint Pacing and radio frequency (RF) telemetry for remote monitoring of patients. MultiPoint Pacing delivers two left ventricular (LV) pulses from a single Quartet™ LV lead for greater tissue capture.1-3
MULTIPOINT™ PACING RESULTS
U.S. IDE Study: Evidence for Improved Outcomes4
The recent IDE study4 post-hoc subanalysis (n = 199) showed that wider cathode spacing and near-simultaneous intraventricular timing delays provide best MPP™ technology response at 87 percent and “super-response” at 54 percent (52 patients).4
MultiPoint™ Pacing Has Also Demonstrated:
- 90% response rate with MultiPoint Pacing at 12 months measured by ESV decrease > 15%5
- 95% response rate with MultiPoint Pacing at 12 months measured by ≥ 1 decrease in NYHA class5
- 90% response rate with MultiPoint Pacing at 12 months measured by Packer’s score5
- 19% absolute improvement in patients for CRT response at 12 months when compared to traditional biventricular (BiV) pacing with a quadripolar lead6
- 44% relative reduction in non-responders at 12 months when compared to traditional BiV pacing with a quadripolar lead6
ELECTRICAL, MECHANICAL AND HEMODYNAMIC BENEFITS
- MultiPoint Pacing was able to recruit a greater portion of the LV than traditional BiV pacing, resulting in reduced activation times and QRS duration.7
- MultiPoint Pacing reduced mechanical dyssynchrony by more than 20% as measured with tissue Doppler imaging in 63% of 41 patients tested.3
- MultiPoint Pacing improved acute LV contractility assessed with pressure wire in 84% of patients compared to BiV pacing.8
- Multiple studies have shown improvement in QRS duration, EF and ESV at six months.9-11
ENHANCED PROGRAMMING OPTIONS
- SyncAV™ CRT technology automatically adjusts pacing based on real-time changes in a patient's cardiac condition.
MANAGE HEART FAILURE WITH INSIGHTFUL DIAGNOSTICS AND RF MONITORING
Quadra Allure MP CRT-P helps you better manage your patients’ heart failure with intuitive programming options and timely access to their vital heart failure diagnostic data through RF monitoring.
- CorVue™ congestion monitoring for an earlier insight into HF progression
- Daily remote monitoring of AT/AF alerts for changes in the patient’s AF condition
- DirectTrend™ reports for a simplified look at all device data
DESIGNED TO OPTIMIZE TISSUE SELECTION
The Quadra Allure MP CRT-P offers Auto VectSelect Quartet™ Test that:
- Automatically identifies tissue sites with the latest activation via RV-LV conduction delays measurements
- Performs threshold testing, assesses LVCap™ Confirm applicability and allows marking of PNS
Pacing at the tissue site of latest activation improves:
- Acute hemodynamic response12
- Reverse remodeling13
- Quality of life13
BUILDING COMPREHENSIVE HEART FAILURE MANAGEMENT
The Quadra Allure MP™ CRT-P is one of our heart failure management therapies. Our vision is to transform the treatment of heart failure by designing technology that delivers excellent clinical outcomes and improves workflow and efficiency. Read more about our approach to heart failure management.
RESOURCES AND DOCUMENTATION
Product Manuals (Instructions for Use)
MultiPoint™ Pacing Clinical Compendium
More Options for Heart Failure Patients: CRT Portfolio Flyer
a. See the MRI Ready Systems Manual for approved MR Conditional Systems Device/Lead combinations and scan parameters.
1. Pappone, C., Calovic, Z., Vicedomini, G., Cuko, A., McSpadden, L. C., Ryu, K., … Santinelli, V. (2014). Multipoint left ventricular pacing improves acute hemodynamic response assessed with pressure-volume loops in cardiac resynchronization therapy patients. Heart Rhythm, 11(3), 394-401. http://dx.doi.org/10.1016/j.hrthm.2013.11.023
2. Rinaldi, C. A., Kranig, W., Leclercq, C., Kacet, S., Betts, T., Bordachar, P., … Nagvi, T. Z. (2013). Acute effects of multisite left ventricular pacing on mechanical dyssynchrony in patients receiving cardiac resynchronization therapy. Journal of Cardiac Failure, 19(11), 731-738. http://dx.doi.org/10.1016/j.cardfail.2013.10.003
3. Endrj, M., Ballari, G. P., Goletto, C., Rossetti, G., & Vado, A. (2015). Characterization of ventricular activation pattern and acute hemodynamics during multipoint left ventricular pacing. Heart Rhythm, 12(8), 1762-1769. http://dx.doi.org/10.1016/j.hrthm.2015.04.029
4. Tomassoni, G., Baker II, J., Corbisiero, R., Love, C., Martin, D., Sheppard, R., Worley, S., Varma, N., Niazi, I. (2016, May).Safety and efficacy of multipoint pacing in cardiac resynchronization therapy: The MultiPoint Pacing (MPP) IDE Study. Presented at the meeting of the Heart Rhythm Society, San Francisco,CA, LBCT 01-03.
5. Zanon, F., Marcantoni, L., Baracca, E., Pastore, G., Lanza, D., Aggio, A., … Prinzen, F. (2016, April). Acute optimization of left ventricular pacing site plus multipoint pacing improve remodeling and clinical response of CRT at one year follow up. Presented at the meeting of the American College of Cardiology, Chicago, IL, Abstract 1194M-03.
6. Pappone, C., Ćalović, Ž., Vicedomini, G., Cuko, A., Mcspadden, L. C., Ryu, K., … Santinelli, V. (2015). Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: Twelve-month follow-up study. Heart Rhythm, 12(6), 1250-1258. http://dx.doi.org/10.1016/j.hrthm.2015.02.008
7. Menardi, E., Ballari, G. P., Goletto, C., Rossetti, G., & Vado, A. (2015). Characterization of ventricular activation pattern and acute hemodynamics during multipoint left ventricular pacing. Heart Rhythm, 12(8), 1762-1769. http://dx.doi.org/10.1016/j.hrthm.2015.04.029
8. Thibault, B., Dubuc, M., Khairy, P., Guerra, P. G., Macle, L, Rivard, L., … Farazi, T. G. (2013). Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead. Europace, 15(7), 984-991. http://dx.doi.org/10.1093/europace/eus435
9. Forleo, G. B., Santini, L., Zanon, F., Di Stolfo, G., Baracca, E., Lucciola, M. T., ... Potenza, D. R. (2015). A new algorithm for multi point pacing in cardiac resynchronization therapy: Feasibility from a multicenter experience. Heart Rhythm, 12(Suppl. 5), S220, HRS poster PO02-190.
10. Forleo, G. B., Santini, L., Potenza, D., Di Stolfo, G., Locatelli, A., Baracca, E., ... Zanon, F. (2015). Impact of Multi-point left ventricular pacing on QRS duration and left ventricular ejection fraction: Preliminary results from a multicenter prospective study. Heart Rhythm, 12(Suppl. 5), S388, HRS poster PO04-183.
11. Park S. J., Chun, K., & Park, K. (2015). More favorable electrical and mechanical reverse remodeling after cardiac resynchronization therapy with quadripolar versus conventional bipolar lead. Heart Rhythm, 12(Suppl. 5), HRS abstract AB28-05.
12. Yu, Y., Auricchio, A., Butter, C., Stellbrink, C., Vogt, J., Goehring, A., & Spinelli, J. (2002). Assessment of resynchronization effectiveness of left ventricular lead site. Journal of Cardiac Failure, 8(4S), S72.
13. Gold, M., Birgersdotter-Green, U., Singh J., Ellenbogen, K., Yu, Y., Meyer, T., ... Tchou, P. (2011).The relationship between ventricular electrical delay and left ventricular remodeling with cardiac resynchronization therapy. European Heart Journal, 32(20), 2516-2524. http://dx.doi.org/10.1093/eurheartj/ehr329