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XIENCE™ FAMILY OF DRUG ELUTING STENTS

THE WORLD'S LEADING DRUG-ELUTING STENTS (DES), WITH UNPARALLELED CLINICAL OUTCOMES1

     

            XIENCE™ SIERRA

Better Expansion

Broadest Expansion Range Among XIENCE™ Stents2

XIENCE Skypoint™ Stent has improved maximum expansion compared to previous generations, so interventional cardiologists (ICs) can use XIENCE™ Stents to treat a broader range of vessels.

XIENCE Skypoint Stent Maximum Expansion

Expansion up to 5.75 mm

For ICs encountering larger vessels, this stent provides significant stent expansion: up to 5.75 mm when deploying 3.5, 4.0, 4.5, and 5.0 mm stents.

Smaller stents—2.25, 2.5, 2.75, 3.0, 3.25 mm lengths—continue to expand to 3.75 mm.2

XIENCE DES Stent Expansion Ranges

Even with greater expansion options, XIENCE™ Stents exhibit Minimal Shortening.3 This can help to ensure accurate stent placement and reduce the risk of geographic miss, which has been reported in over 30% of percutaneous coronary interventions (PCI).4

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XIENCE Skypoint™ Stent for Tapered Lesions

XIENCE Skypoint™ Stent exhibits excellent expansion and apposition for a wide range of vessel sizes while also delivering optimal patient outcomes.5 Moreover, treating long, tapered lesions is practical with a single stent, especially since the XIENCE Skypoint™ Stent is available in a 48 mm length.6

XIENCE Skypoint DES Stent for Long Tapered Vessel Placement

Large Tapered Vessels: XIENCE Skypoint™ Stent provides a large expansion range designed to help treat patients with large tapered lesions—with a single stent.6

Small Tapered Vessels: Similarly, choosing a smaller diameter XIENCE Skypoint™ Stent allows ICs to treat a small tapered vessel, from 2.25 mm to 3.75 mm.6

XIENCE Skypoint DES Stent for Small Tapered Vessel Placement

Better Longitudinal Strength

The XIENCE™ family of stents are built on the MULTI-LINK platform. Its 3 links per ring connect the peaks of one ring to the valleys of the adjacent ring. This prevents struts from either compressing together or stretching apart.

With the MULTI-LINK stent platform, XIENCE™ Stents have better longitudinal strength, compared to other DES.7 This reduces the possibility of displacement or deformation for XIENCE Skypoint™ Stents.  

Compression tests reveal significantly improved longitudinal strength with XIENCE™ Stents compared to Synergy‡ and Resolute Onyx‡ DES.

XIENCE Stents perform better in longitudinal compression tests compared to Synergy and Resolute Onyx drug-eluting stents.

XIENCE Skypoint™ Stent Comparison: 3.0 mm x 48 mm8

Compression tests of 3.0 mm x 48 mm stents reveal excellent longitudinal strength with XIENCE Skypoint™ Stent—similar to XIENCE Xpedition™ Stent but significantly better than Synergy‡. So even when long lesions require PCI, the longitudinal strength of XIENCE Skypoint™ Stent sets it apart from other DES.

Using 48-mm stent lengths, XIENCE Skypoint Stent performs significantly better in longitudinal compression tests compared to Synergy DES; XIENCE Skypoint and XIENCE Xpedition results are the same.

Lower Crossing Profile on 48 mm Length9

For long lesions, the 48 mm XIENCE Skypoint™ Stent, compared to the XIENCE Xpedition™ Stent, is designed with narrower crests and tighter nesting. These features allow for a lower crossing profile of just 0.041".

For long lesions, the 48-mm XIENCE Skypoint™ Stent is designed with narrow crest and tight nesting.

Better Expansion on 48 mm Length10

For long lesions, the 48 mm XIENCE Skypoint™ Stent’s design enhancements allow for improved expansion. Compared to the XIENCE Xpedition™ Stent, XIENCE Skypoint™ Stent is designed with elongated bar arms—offering better post-dilation (5.75 mm) expansion.

Together, all of these features lead to trusted patient outcomes, regardless of the diameter and length of the XIENCE Skypoint™ Stent deployed.

The 48-mm XIENCE Skypoint™ Stent’s design enhancements allow for improved expansion.

Abbott’s Coronary Intervention Portfolio

References

  1. Zanchin C, et al. JACC Cardiovasc Interv. 2019;12(17):1665-1675. Serruys P, et al. N Engl J Med. 2010;363:136-146. Shiomi H, et al. JACC Cardiovasc Interv. 2019;12:637-647. Kufner S, et al. Circulation. 2019:139(3):325-333. Palmerini T, et al. Lancet. 2013;379:1393-1402. Bangalore S, et al. Circulation. 2012;125:2873-2891. Bangalore S, et al. Circ Cardiovasc Interv. 2013;6(6):378-390. Pilgrim T, et al. Lancet. 2014;384:2111-2122. Pilgrim T, et al. Lancet. 2018;392:737-746. Data on file at Abbott.
  2. XIENCE Skypoint™ Instructions For Use (IFU). Refer to IFU for additional information. XIENCE Skypoint™ Stent compared with XIENCE Sierra™ Stent, 3.5 x 18 mm stent expanded to 5.75 mm. Acceptance criterion allows 10% as maximum.
  3. Data on file at Abbott. Comparison is between XIENCE Skypoint™ Stent, Synergy‡ and Resolute Onyx‡—3.5 x 18 mm or 20 mm stents tested and expanded to maximum labelled expansion limit.
  4. Calvert PA. Catheter Cardiovasc Interv. 2016;88(3):340-347.
  5. Sudhir K, et al. ISRN Cardiol. 2013:748736.
  6. XIENCE Skypoint™ IFU.
  7. Data on file at Abbott. XIENCE Sierra™ Stent (5.0 x 33 mm) n=5, SYNERGY‡ (5.0 x 32 mm) n=5, Resolute Onyx‡ (5.0 x 33 mm) n=5.
  8. Data on file at Abbott. XIENCE Skypoint™ Stent (3.0 x 48 mm) n=4, XIENCE Xpedition™ Stent (3.0 x 48 mm) n=5, SYNERGY‡ (3.0 x 48 mm) n=3.
  9. Data on file at Abbott. Average stent profile: XIENCE Skypoint™ Stent 3.0 x 48 mm compared with XIENCE Xpedition™ Stent 3.0 x 48 mm. Note: Small stent designs include 2.5 x 48 mm, 2.75 x 48 mm and 3.0 x 48 mm sizes
  10. Data on file at Abbott. Note: Elongated bar arms is for medium stent design (9-crest design), 3.5 mm and 4.00 mm.

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