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CARDIOVASCULAR
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Von Willebrand Factor Degradation in HeartMate 3 vs HeartMate II LVAD

Bansal, A. Uriel, N., Colombo, P.C., Narisetty, K., Long, J.W., …Mehra, M.R. (2019). Effects of a Fully Magnetically Levitated Centrifugal-Flow or Axial-Flow Left Ventricular Assist Device on Von Willebrand Factor: A Prospective Multicenter Clinical Trial. J Heart Lung Transplant. https://doi.org/10.1016/j.healun.2019.05.006

This analysis evaluated the structure and functional characteristics of von Willebrand factor (vWF) high molecular weight multimers (HMWMs) in patients with the fully magnetically levitated centrifugal-flow HeartMate 3 (HM3) and the continuous axial-flow HeartMate II (HMII) pump. The data from this analysis demonstrates:

  • Significantly greater preservation of vWF HMWM was seen with HeartMate 3 compared to HeartMate II
  • Functional attributes of vWF are within normal range post-LVAD
  • vWF HMWM alterations but not functional changes are correlated with bleeding in HeartMate 3

MAT-2006844 v1.0

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DO YOU WISH TO CONTINUE AND EXIT CARDIOVASCULAR.ABBOTT?

CONTENTS OF THE SITE ARE NOT UNDER THE CONTROL OF ABBOTT.