CARDIOVASCULAR
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EPIC. BY DESIGN.

The Epic stented tissue valve with Linx anticalcification (AC) technology is engineered to deliver excellent durability and performance, as well as smooth, streamlined implantability.

With the lowest overall ventricular protrusion in all valve sizes,1-5 the Epic Mitral valve is an excellent choice for the mitral position. With its low profile, the Epic heart valve can:

  • Reduce the risk of left ventricular outflow tract obstruction6
  • Avoid requiring a specific orientation during implantation
  • Allow for easy implantability during minimally invasive surgery (MIS)

The Epic Mitral valve is based on the same design as the Biocor valve, a bioprosthetic heart valve that is supported by 20 years of published durability data and 25 years of clinical experience.

LINX AC TECHNOLOGY

Abbott’s unique Linx AC technology—to promote anti-calcification*—is designed to improve long-term performance and valve durability. The Linx AC treatment has demonstrated resistance to calcification by:

  • Extracting lipids7
  • Reducing free aldehydes8,9
  • Minimizing cholesterol uptake10
  • Stabilizing leaflet collagen10

* No clinical data currently available have evaluated the long-term impact of anti-calcification tissue treatment in humans

EPIC MITRAL VALVE DURABILITY AND ENHANCED CONTROL

The Epic Mitral valve’s triple composite design and unique pericardial shield are designed for durability. To facilitate the implant procedure, the Epic valve also features the FlexFit system, comprised of:

  • A flexible polymer stent
  • Ratcheting holder
  • Rinse time of 2 x 10 seconds

 

 

References

1. Epic valve [package insert]. Chicago, IL: Abbott; table 1.
2. Carpentier-Edwards PERIMOUNT THEON Mitral Replacement System Brochure. #AR00856. 
3. Edwards PERIMOUNT Magna Mitral Pericardial Bioprosthesis Brochure. #AR01603. 
4. Medtronic Mosaic Bioprosthesis Aortic and Mitral Brochure. #UC200103933b EN. 
5. Medtronic Hancock II and Hancock II Ultra Bioprosthesis Brochure.
6. Guler N, Ozkara C, Akyol A. Left ventricular outflow tract obstruction after bioprosthetic mitral valve replacement with posterior mitral leaflet preservation. Tex Heart Inst J. 2006;33:399-401.
7. Vyavahare, N, Hirsch, D, Lerner, E, et al. Prevention of bioprosthetic heart valve calcification by ethanol preincubation. Circulation. 1997:95;479-488. doi.org/10.1161/01.CIR.95.2.479.
8. Kelly SJ, Ogle MF, Carlyle WC, et al. Biocompatibility and calcification of bioprosthetic heart valves. Presented at: Society for Biomaterials, Sixth World Biomaterials Congress Transaction. May 2000:1353. 
9. Frater RWM, Seifter E, Liao K, et al. Chapter 8. In: Gabbay, S, Wheatley DJ, eds. Advances in Anticalcific and Antidegenerative Treatment of Heart Valve Bioprostheses. 1st ed. Austin: Silent Partners, Inc; 1997:105-113.
10. Vyavahare NR, Hirsch D, Lerner E, et al. Prevention of calcification of glutaraldehyde-crosslinked porcine aortic cusps by ethanol preincubation: mechanistic studies of protein structure and water-biomaterial relationships. J Biomed Mater Res. 1998;40:577-585.

DESIGNED TO BE VERSATILE AND MADE TO BE ADAPTABLE

The Epic Mitral valve achieves minimal valvular regurgitation by providing two features crucial in the mitral position: impressive paravalvular cuff sealing and central leaflet coaptation.

The valve’s innovative triple composite design uses 3 separate porcine leaflets to optimize leaflet coaptation, reduce stress, and mitigate regurgitation. The conformable sewing cuff further minimizes regurgitation in high-risk anatomies, such as calcified mitral annulus.

THE INNOVATIVE FLEXFIT SYSTEM

Epic heart valve features

 

References

1. Epic valve [package insert]. Chicago, IL: Abbott; table 1.
2. Carpentier-Edwards PERIMOUNT THEON Mitral Replacement System Brochure. #AR00856. 
3. Edwards PERIMOUNT Magna Mitral Pericardial Bioprosthesis Brochure. #AR01603. 
4. Medtronic Mosaic Bioprosthesis Aortic and Mitral Brochure. #UC200103933b EN. 
5. Medtronic Hancock II and Hancock II Ultra Bioprosthesis Brochure.
6. Guler N, Ozkara C, Akyol A. Left ventricular outflow tract obstruction after bioprosthetic mitral valve replacement with posterior mitral leaflet preservation. Tex Heart Inst J. 2006;33:399-401.

EXCEPTIONAL DURABILITY COMPARED TO OTHER SURGICAL MITRAL VALVES

Durability is a critical factor to consider with bioprosthetic heart valves, and the Epic Mitral valve has an impressive long-term track record of 10-year durability.


Freedom from Structural Valve Deterioration7

Epic Mitral Valve outperforms other valves


Freedom from Reoperation due to Structural Valve Deterioration

Epic Mitral Valve outperforms other valves

When evaluating data from the Epic valve’s predecessor, the Biocor valve,8 its durability is impressive compared to competitors the Perimount valve9 and the Hancock II valve.10,*


*Results from different clinical trials are not directly comparable. Information provided for educational purposes only.

 

References

1. Epic valve [package insert]. Chicago, IL: Abbott; table 1.
2. Carpentier-Edwards PERIMOUNT THEON Mitral Replacement System Brochure. #AR00856.
3. Edwards PERIMOUNT Magna Mitral Pericardial Bioprosthesis Brochure. #AR01603.
4. Medtronic Mosaic Bioprosthesis Aortic and Mitral Brochure. #UC200103933b EN.
5. Medtronic Hancock II and Hancock II Ultra Bioprosthesis Brochure.
6. Guler N, Ozkara C, Akyol A. Left ventricular outflow tract obstruction after bioprosthetic mitral valve replacement with posterior mitral leaflet preservation. Tex Heart Inst J. 2006;33:399-401
7. Lehmann S, Jawad K, Meyer A, et al. Long-term follow-up after porcine xenograft mitral valve replacement. Presented at: American Association for Thoracic Surgery Mitral Conclave; April 27-28, 2017; New York, NY USA.
8. Mykén PS, Bech-Hansen O. A 20-year experience of 1712 patients with the Biocor porcine bioprosthesis. J Thorac Cardiovasc Surg. 2009;137:76-81.
9. Bourguignon T, Bouquiaux-Stablo AL, Loardi C, et al. Very late outcomes for mitral valve replacement with the Carpentier-Edwards pericardial bioprosthesis: 25-year follow-up of 450 implantations. J Thorac Cardiovasc Surg. 2014;148:2004-2011.
10. Borger MA, Ivanov J, Armstrong S, et al. Twenty-year results of the Hancock II bioprosthesis. J Heart Valve Dis. 2006;15:49-56.

EPIC MITRAL VALVE ORDERING INFORMATION

Model Number

Valve Size (mm)

Tissue Annulus Diameter (mm)

Internal Diameter (Stent ID mm)

Ventricular Protrusion (mm)

Total Height (mm)

E100-25M-00

25

25

23

9

16

E100-27M-00

27

27

25

9

17

E100-29M-00

29

29

27

10

19

E100-31M-00

31

31

29

10

20

E100-33M-00

33

33

31

11

20

 

References

1. Epic valve [package insert]. Chicago, IL: Abbott; table 1.
2. Carpentier-Edwards PERIMOUNT THEON Mitral Replacement System Brochure. #AR00856. 
3. Edwards PERIMOUNT Magna Mitral Pericardial Bioprosthesis Brochure. #AR01603. 
4. Medtronic Mosaic Bioprosthesis Aortic and Mitral Brochure. #UC200103933b EN. 
5. Medtronic Hancock II and Hancock II Ultra Bioprosthesis Brochure.
6. Guler N, Ozkara C, Akyol A. Left ventricular outflow tract obstruction after bioprosthetic mitral valve replacement with posterior mitral leaflet preservation. Tex Heart Inst J. 2006;33:399-401.

AP2946720-WBO Rev. A

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